Radiobiological Optimization in Lung Stereotactic Body Radiation Therapy: Are We Ready to Apply Radiobiological Models?
نویسندگان
چکیده
منابع مشابه
Radiobiological Optimization in Lung Stereotactic Body Radiation Therapy: Are We Ready to Apply Radiobiological Models?
Lung tumors are often associated with a poor prognosis although different schedules and treatment modalities have been extensively tested in the clinical practice. The complexity of this disease and the use of combined therapeutic approaches have been investigated and the use of high dose-rates is emerging as effective strategy. Technological improvements of clinical linear accelerators allow c...
متن کاملRadiobiological mechanisms of stereotactic body radiation therapy and stereotactic radiation surgery
Despite the increasing use of stereotactic body radiation therapy (SBRT) and stereotactic radiation surgery (SRS) in recent years, the biological base of these high-dose hypo-fractionated radiotherapy modalities has been elusive. Given that most human tumors contain radioresistant hypoxic tumor cells, the radiobiological principles for the conventional multiple-fractionated radiotherapy cannot ...
متن کاملStereotactic body radiation therapy (SBRT) and respiratory gating in lung cancer: dosimetric and radiobiological considerations
The purpose of this study was to assess the impact of respiratory gating on tumor and normal tissue dosimetry in patients treated with SBRT for early stage non-small cell lung cancer (NSCLC). Twenty patients with stage I NSCLC were studied. Treatment planning was performed using four-dimensional computed tomography (4D CT) with free breathing (Plan I), near-end inhalation (Plan II), and near-en...
متن کاملRadiobiological impact of dose calculation algorithms on biologically optimized IMRT lung stereotactic body radiation therapy plans
BACKGROUND The aim of this study is to evaluate the radiobiological impact of Acuros XB (AXB) vs. Anisotropic Analytic Algorithm (AAA) dose calculation algorithms in combined dose-volume and biological optimized IMRT plans of SBRT treatments for non-small-cell lung cancer (NSCLC) patients. METHODS Twenty eight patients with NSCLC previously treated SBRT were re-planned using Varian Eclipse (V...
متن کاملRadiobiological Measurements for Radiation Therapy: Extension to Other Ions*
Introduction A combined proton and carbon machines is used in Heidelberg (HIT) and will be running in Pavia, Marburg, and Kiel. In addition to proton and carbon it might be possible that several other ions can offer specific advantages which need to be investigated. In this report data from Li as lighter ion and N as heavier ion are shown. For the heavier ion, especially measurements under diff...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2018
ISSN: 2234-943X
DOI: 10.3389/fonc.2017.00321